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目的 探讨肿瘤坏死因子α(TNFα)、一氧化氮(NO)在婴幼儿肺炎及肺炎并心力衰竭中的作用。方法 采用高效液相色谱技术等方法测定60例婴幼儿肺炎及30例健康对照儿童外周血TNFα、NO及肌酸激酶同功酶(CK-MB)。结果 肺炎组与对照组比较,TNFα、NO、CK-MB均显著增高。心衰组与肺炎组比较,仅TNFα、CK-MB增高有显著性差异。TNFα与CK-MB呈高度正相关。结论 TNFα、NO造成婴幼儿肺炎时心肌细胞的损伤,参与了心力衰竭的发生、发展
Objective To investigate the role of tumor necrosis factor α (TNFα) and nitric oxide (NO) in infantile pneumonia and pneumonia with heart failure. Methods The serum levels of TNFα, NO and CK-MB in 60 infantile pneumonia and 30 healthy controls were measured by high performance liquid chromatography (HPLC). Results pneumonia group compared with the control group, TNFα, NO, CK-MB were significantly higher. Heart failure group and pneumonia group, only TNFα, CK-MB increased significantly. TNFα was positively correlated with CK-MB. Conclusions TNFα, NO caused myocardial cell injury in infants with pneumonia and participated in the occurrence and development of heart failure