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用骨形成蛋白(BMP)与钛心多孔羟基磷灰石(HA)涂层种植体复合,制成 BMP-HA复合种植体,在10例病人15个缺牙区用15枚该复合种植体进行种植;同时对条件相似的11例病人的缺牙区植入15枚HA涂层种植体作为对照.追踪观察每枚种植体的不同期X线牙片、种植体的松动度,判定种植体周围的新骨修复情况.结果发现:BMP-HA复合种植体周围的新骨形成速度和成骨量高于HA涂层种植体、同时发现,种植4周后,两组患者血清中碱性磷酸酶(ALP)的活性均高于种植前,而BMP—HA复合种植体组患者血清中ALP活性又高于HA种植体组.因此植入前后患者血清中ALP活性的改变可能反映了种植体周围的新骨形成速度和成骨量的情况.
Bone morphogenetic protein (BMP) was combined with titanium hydroxyapatite (HA) coated implant to make BMP-HA composite implant, and 15 composite implants were used in 15 edentulous areas of 10 patients At the same time, 15 HA-coated implants were implanted in the edentulous area of 11 patients with similar conditions as the control.Looking at different periods of each implant, the degree of loosening of X-ray teeth and implants was observed to determine the implants around the implants The results showed that the rate of new bone formation and osteogenesis around BMP-HA composite implants were higher than those of HA-coated implants, and at 4 weeks after implantation, the levels of alkaline phosphatase (ALP) were higher than those before planting, while ALP activity in serum of BMP-HA composite implant group was higher than that of HA implant group.Therefore, the change of ALP activity in serum of patients before and after implantation may reflect the changes of New bone formation and osteogenesis.