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目的探讨血小板在诊治手足口病中的临床价值。方法手足口病患儿1 253例,其中1期1 123例、2期117例、3期5例、4期8例,检查患儿血小板参数和凝血功能。结果血小板数量随手足口病病情加重而增加(P<0.05);4期组凝血酶原时间、活化部分凝血酶原时间、凝血酶时间均长于1期组、2期组、3期组(P均<0.01),抗凝血酶原Ⅲ,纤维蛋白原,D-二聚体、国际标准化比值显著高于1期组、2期组、3期组(P均<0.01)。结论随着手足口病病情加重,患儿血小板数目增加,同时凝血酶原时间延长和D-二聚体含量增加。
Objective To investigate the clinical value of platelet in the diagnosis and treatment of hand-foot-mouth disease. Methods A total of 1 253 children with HFMD were enrolled, including 1 123 cases in stage 1, 117 cases in stage 2, 5 cases in stage 3 and 8 cases in stage 4. Platelet parameters and coagulation function in children were examined. Results The number of platelets increased with the increase of HFMD (P <0.05). The prothrombin time, partial prothrombin time, and thrombin time of group 4 were longer than those of group 1, 2 and 3 (All P <0.01). The ratio of antithrombin Ⅲ, fibrinogen and D-dimer was significantly higher than that of the first phase, the second phase and the third phase (all P <0.01). Conclusions With the aggravation of hand-foot-mouth disease, the number of platelets in children increases and the prothrombin time prolongs and the content of D-dimer increases.