Objective:To investigate the expression and potential roles of G protein—coupled receptor kinase 6[GRK6]in hepatocellular carcinoma(HCC) patients.Methods:Immunohistochemistry and Western blot was performed to determine GRK6 expression in 73 HCC samples.And the correlation with clinieopathological features was also analyzed.Results:GKK6 expression was significantly higher in HCC than that in normal hepatic tissue.GRK6 was positively correlated with proliferation marker Ki-67,clinical stage,metastasis and survival time.Conclusions: Our results suggested that GUK.6 overexpression plays an important role in HCC.Monitoring the expression of GRK6 maybe helpful in early diagnosis and prognosis of HCC. Objective: To investigate the expression and potential roles of G protein-coupled receptor kinase 6 [GRK6] in hepatocellular carcinoma (HCC) patients. Methods: Immunohistochemistry and Western blot was performed to determine GRK6 expression in 73 HCC samples. And the correlation with clinieopathological features was also analyzed. Results: GKK6 expression was significantly higher in HCC than that in normal hepatic tissue. GRK6 was positively correlated with proliferation marker Ki-67, clinical stage, metastasis and survival time. Confclusions: Our results suggested that GUK.6 overexpression plays an important role in HCC. Monitor the the expression of GRK6 maybe helpful in early diagnosis and prognosis of HCC.