【摘 要】
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Alterations in cell metabolism are a characteristic of many cancers.Cancer cells are metabolically rewired to support their rapid growth (Kim and Dang,2006;Vand
【机 构】
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Key Laboratory of System Biology and Shanghai Key Laboratory of Molecular Andrology, Institute of Bi
论文部分内容阅读
Alterations in cell metabolism are a characteristic of many cancers.Cancer cells are metabolically rewired to support their rapid growth (Kim and Dang,2006;Vander Heiden et al.,2009).The best-characterized metabolic phenotype observed in tumor cells is aerobic glycolysis,also known as the Warburg effect,which is a shift of ATP generation from high efficient oxidation phosphorylation to low efficient glycolysis even under normal oxygen concentration (Gatenby and Gillies,2004;Warburg,1956).Pyruvate kinase catalyzes the final step in glycolysis by transferring the phosphate from phosphoenolpyruvate (PEP) to ADP,thereby generating pyruvate and ATP (Altenberg and Greulich,2004;Corcoran et al.,1976).In mammals,pyruvate kinase is encoded by two genes,PKLR and PKM (Noguchi et al.,1987).
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