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黄曲霉毒素B_1(AFB_1)是自然产生的一种霉菌毒素,它是一种强致癌剂,本文对AFB_1对淋巴细胞功能的影响进行了研究。体内实验采用7周龄BALB/C小鼠,分别经口给予0、0.003、0.145、及0.7mg/kg AFB_1。染毒后做如下测试:1.一般毒性病理检查。2.用[~3H]亮氨酸掺入法测定脾淋巴细胞蛋白质合成,用[~3H]尿嘧啶掺入法测定其RNA合成情况,用[~3H]胸腺嘧啶(~3HTdR)法测定小鼠染毒后在脂多糖(LPS)、美洲商陆(PWM)、植物血凝素(PHA)、刀豆蛋白(Con
Aflatoxin B_1 (AFB_1) is a naturally occurring mycotoxin that is a potent carcinogen. The effects of AFB_1 on lymphocyte function were studied in this paper. In vivo experiments 7-week-old BALB / C mice were orally administered with 0, 0.003, 0.145, and 0.7 mg / kg AFB_1, respectively. Following exposure to the following tests: 1. General toxicological examination. The protein synthesis of splenic lymphocytes was measured by incorporation of [~ 3H] leucine, and the RNA synthesis was measured by [~ 3H] uracil incorporation method. The [~ 3H] thymidine After the mice were infected with the lipopolysaccharide (LPS), pokeweed (PWM), phytohemagglutinin (PHA), Cone (Con