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研究运动对链脲佐菌素所致糖尿病大鼠A SP的影响。选用雄性SD大鼠,随机分为4组(每组10只),即:正常对照组,正常运动组,糖尿病模型组,糖尿病模型+运动组。运动组进行10周的游泳训练。结果表明:1)糖尿病模型组与正常对照组大鼠相比,血浆A SP浓度、血糖、TG、和LDL明显升高,血清FFA有升高趋势,血清胰岛素和IS I明显降低;2)糖尿病模型+运动组较其非运动组血浆A SP浓度、血糖、TG、TC、FFA和LDL明显降低,血清胰岛素和HDL含量明显升高。提示:糖尿病机体血浆A SP浓度升高,伴随着其活性下降,使得FFA和富含TG的脂蛋白消除障碍,长期中等负荷运动可以降低血浆中A SP浓度,增加其活性,进而降低FFA和TG水平,升高HDL,改善糖尿病机体的脂质代谢,预防其慢性并发症的发生。
To study the effect of exercise on A SP in streptozotocin-induced diabetic rats. Male SD rats were randomly divided into 4 groups (10 in each group), namely: normal control group, normal exercise group, diabetic model group, diabetic model + exercise group. Exercise group for 10 weeks of swimming training. The results showed that: 1) Compared with normal control group, plasma ASP concentration, blood glucose, TG, and LDL were significantly increased in diabetic model group and serum FFA levels were increased, serum insulin and ISI were significantly decreased; 2) Compared with the non-exercise group, the levels of plasma A SP, blood glucose, TG, TC, FFA and LDL in model + exercise group were significantly decreased, and the levels of serum insulin and HDL were significantly increased. It is suggested that the increase of plasma A SP concentration in diabetes mellitus, accompanied with the decrease of its activity, makes the elimination of FFA and TG-rich lipoprotein obstructive. Long-term moderate exercise can reduce the concentration of A SP in plasma and increase its activity, thereby reducing the FFA and TG Level, raise HDL, improve lipid metabolism of diabetic body and prevent its chronic complications.