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目的了解乙型肝炎(乙肝)表面抗原(HBsAg)阳性人群的转归及家庭成员感染HBV的情况。方法 2009年12月对HBsAg阳性人群(16例)及家庭成员进行HBsAg检测,阳性人员再进行肝功能和血常规(白细胞、血小板)、HBV标志物检测、临床检查以及B超检查,对HBsAg阳性人员进行分类诊断。结果共检测44份血清,其中HBsAg阳性16份(仍为2006年HBsAg阳性者)其余家庭成员HBsAg均阴性。3年内HBsAg阳转阴率为0,仅携带HBsAg者4例(25.0%),慢性肝炎病人为10例(62.5%),脂肪肝(轻度)2例,肝硬化为0,无转为肝细胞癌(HCC)者,感染乙肝病毒又感染丙肝病毒的1例。结论 HBsAg阳性者转阴的概率很小,应定期进行查体和继续关注其密切接触者。
Objective To understand the outcome of hepatitis B (HBsAg) positive population and HBV infection among family members. Methods In December 2009, HBsAg was detected in HBsAg positive patients (16 cases) and their family members. The positives were tested for liver function and blood routine (leukocyte and platelet), HBV markers, clinical examination and B-ultrasound. HBsAg positive Personnel classification diagnosis. Results A total of 44 sera were detected, of which 16 were HBsAg-positive (still HBsAg positive in 2006) and the rest of the family members were negative for HBsAg. 3 years HBsAg positive negative rate of 0, only HBsAg in 4 cases (25.0%), chronic hepatitis patients in 10 cases (62.5%), fatty liver (mild) in 2 cases, liver cirrhosis was 0, no conversion to liver 1 case of cell carcinoma (HCC), hepatitis B virus infection and hepatitis C virus infection. Conclusions HBsAg positive patients have a very low probability of negative conversion. They should be checked regularly and their follow-up attention should be continued.