论文部分内容阅读
目的:研究梓醇对鱼藤酮所致小鼠脑线粒体损伤的保护作用。方法:小鼠随机分为对照组、模型组和治疗组。模型组腹腔注射鱼藤酮21d;治疗组先注射鱼藤酮21 d,后用梓醇治疗10 d。测定小鼠中脑、纹状体和皮层中线粒体复合酶Ⅰ、谷胱甘肽(GSH)、乳酸脱氢酶(LDH)活性、膜电位、活性氧(ROS)的含量。结果:梓醇能够提高小鼠复合酶Ⅰ活性,增加GSH的含量,减少膜电位的丢失和活性氧的生成,抑制LDH的释放。结论:梓醇对鱼藤酮损伤小鼠脑线粒体具有保护作用。
Objective: To study the protective effect of catalpol on brain mitochondrial damage induced by rotenone in mice. Methods: The mice were randomly divided into control group, model group and treatment group. The model group was treated with intraperitoneal injection of rotenone for 21 days. The treatment group received rotenone for 21 days and catalpol treatment for 10 days. The levels of mitochondrial synthase I, glutathione (GSH), lactate dehydrogenase (LDH), membrane potential and reactive oxygen species (ROS) in midbrain, striatum and cortex of mice were determined. Results Catalpol increased the activity of compound enzyme Ⅰ, increased the content of GSH, reduced the loss of membrane potential and the generation of reactive oxygen species, and inhibited the release of LDH. Conclusion: Catalpol has a protective effect on brain mitochondria of rotenone-injured mice.