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目的:分析硫酸吗啡缓释片肿瘤患者服用时癌痛发作咀嚼后所致ADR原因。方法:患者癌痛发作咀嚼后吗啡所致神志萎靡,眼球震颤上翻,瞳孔直径约1 mm,即予心电监护,并按吗啡中毒给予静脉推注盐酸纳洛酮注射液治疗。结果:患者经救治,停药观察3 h,其神志清,呼吸平稳,症状缓解历时7 h,纳洛酮用量4.8 mg。结论:硫酸吗啡缓释片咀嚼服用后极量吗啡所致呼吸抑制,临床用药时告知患者应吞服硫酸吗啡缓释片,并做好用药教育,教其正确用法。
OBJECTIVE: To analyze the causes of ADR caused by the painful chewing after taking morphine sustained-release tablets. Methods: Patients with cancer pain after chewing morphine apathetic, nystagmus flip, the pupil diameter of about 1 mm, that is, to the ECG, and morphine poisoning intravenous injection of naloxone hydrochloride injection. Results: The patients were treated and discontinued for 3 hours. Their consciousness and breathing were stable. The symptom relief lasted for 7 hours and the dosage of naloxone was 4.8 mg. Conclusion: Morphine sulfate sustained-release tablets chew after taking a large amount of morphine-induced respiratory depression, clinical medication should be informed of patients should swallow morphine sulfate sustained-release tablets, and do medication education, teach the correct usage.