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目的采用事件相关电位(ERP)对纠正胎龄1周早产儿与生后1周足月儿的认知进行比较研究,探索早产儿早期认知特征。方法随机选择健康足月儿(1~7d)30名、早产儿(纠正胎龄1~7d)15名。采用听觉oddball范式,记录听觉事件相关电位(aERP),对两组进行Fz、Cz导联P2、N2波面积比较分析。结果 1)Fz导联,P2、N2波面积早产儿组均小于足月儿组,差异有统计学意义(t=2.133,P=0.039;t=2.230,P=0.031);2)Cz导联,P2、N2波面积早产儿组均小于足月儿组,差异有统计学意义(t=2.107,P=0.041;t=2.179,P=0.035)。结论早产儿(纠正胎龄)第一周感知、识别声音等认知功能落后于同日龄足月儿。
Objective To investigate the cognition characteristics of premature infants with early cognitive function by using incident-related potentials (ERP) to correct the cognition of premature infants of 1 week gestational age and full-term infants of 1 week after birth. Methods Thirty healthy term children (1-7 days) and 15 premature infants (corrected gestational age 1-7 days) were randomly selected. Auditory oddball paradigm was used to record the auditory event-related potentials (aERP). The comparison of the wave areas of P2 and N2 between the Fz and Cz leads was done. Results (1) Fz lead, P2, N2 wave area of preterm children were less than full-term infants, the difference was statistically significant (t = 2.133, P = 0.039; t = 2.230, P = 0.031); 2) Cz lead (P = 0.041; t = 2.179, P = 0.035) in the preterm infants with P2 and N2 wave areas were all lower than those of the full-term infants. Conclusions The cognitive function of the preterm infants (corrected gestational age) in the first week of perception, recognition of sounds lags behind that of full-term infants of the same age.