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目的分析肾癌的危险因素,探讨肾癌与血浆脂代谢水平相关性。方法测定95例肾癌患者和138例非肿瘤患者的血脂水平,并结合肾癌临床分期进行差异性的比较。结果肾癌患者与非肿瘤组患者相比较,肾癌组血浆高密度脂蛋白胆固醇(HDL)较非肿瘤组低,血浆甘油三酯(TG)、极低密度脂蛋白胆固醇(VLDL)则明显升高,两组差异有显著性(P<0.01),在肾癌组患者中,随肿瘤分期的不同,血浆HDL逐渐降低,血浆TG、VLDL则逐渐升高,与Ⅰ期相比较,各组差异均有显著性(P<0.01),而各分组在TC和LDL方面则无显著差异(P>0.05)。结论脂代谢紊乱可能是肾癌的危险因素;血脂水平与肾癌的发生发展有一定的相关性。
Objective To analyze the risk factors of renal cell carcinoma and to explore the correlation between the level of lipid metabolism and renal cell carcinoma. Methods Serum lipid levels were measured in 95 renal cancer patients and 138 non-tumor patients, and the differences were compared with the clinical stage of renal cell carcinoma. Results Compared with non-tumor patients, the levels of plasma HDL in patients with renal cell carcinoma were significantly lower than those in non-tumor patients, while plasma triglyceride (TG) and very low density lipoprotein cholesterol (VLDL) There was significant difference between the two groups (P <0.01). In the patients with renal cell carcinoma, the plasma HDL gradually decreased and the levels of plasma TG and VLDL increased gradually with the different stages of the tumor. Compared with the phase Ⅰ, (P <0.01), while there was no significant difference between TC and LDL (P> 0.05). Conclusion The disorder of lipid metabolism may be the risk factor of renal cell carcinoma. The level of blood lipid is related to the occurrence and development of renal cell carcinoma.