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目的 :为了解血管内皮细胞生长因子 (VEGF)在类风湿关节炎 (RA)病人中的水平。方法 :ELISA双抗夹心法VEGF试剂盒定量测定 ,同时采用BeckmanArray36 0检测血清RF水平。结果 :32例活动性RA病人血清VEGF水平较健康对照组有明显增高 (P <0 0 1)。结论 :提示VEGF参与了RA的发病 ,测定血清VEGF水平是一种无侵入性、实用的监测RA病情的方法。
Objective: To understand the level of vascular endothelial growth factor (VEGF) in rheumatoid arthritis (RA) patients. Methods: The ELISA kit was used to determine the level of serum RF, and BeckmanArray36 0 was used to detect the level of serum RF. Results: Serum VEGF levels in 32 active RA patients were significantly higher than those in healthy controls (P <0.01). Conclusion: It is suggested that VEGF is involved in the pathogenesis of RA. The determination of serum VEGF level is a noninvasive and practical method to monitor the severity of RA.