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目的 建立一种简便、经济、有效、实用, 易为群众接受的胃癌筛查方法。方法 收集江西医学院一附属医院408例胃癌病例,425 例非癌慢性胃病病例和468 例非消化道疾病病例。用 L9ogistic 回归筛出胃癌病人常见的9 项临床表现, 用最大似然判别法建立用于筛查的判别模型和计量诊断表。结果 回代结果显示:早、中、晚期胃癌患者筛检阳性检出率分别 达9259 % 、9538 % 和9618 % ;非癌慢性胃病和非消化道疾病筛检检出率分别达9365 % 、9722 % 。本法敏感度和特异度分别达9142 % 和9726 % ;诊断效率达9577 % ; 可靠达091 。结论 本法具有简便、快速、无损伤、经济、实用、有效、易为群众接受等特点,适合于基层作定期筛查使用。初步结果表明, 本法的筛查效果是好的,收益是高的, 可望能为胃癌的防治工作提供一条新的思路。
Objective To establish a simple, economical, effective, practical and easy-to-apply method for gastric cancer screening. Methods A total of 408 cases of gastric cancer were collected from a affiliated hospital of Jiangxi Medical College, 425 cases of non-cancerous chronic gastritis and 468 cases of non-digestive diseases. Nine common clinical manifestations of gastric cancer patients were screened out by L9ogistic regression, and the discriminative model and diagnostic questionnaire used for screening were established using the maximum likelihood method. The results of the retrospective results showed that the positive rate of screening in early, middle and late gastric cancer patients was 92 59 %, 95 38 % and 96 18 %, respectively; the screening rate of non-cancerous chronic gastritis and non-digestive disease screening Respectively 93 65%, 97 22%. The sensitivity and specificity of this method reached 9142% and 9726% respectively; the diagnostic efficiency reached 9577%; the reliability reached 091. Conclusion This method is simple, rapid, non-invasive, economical, practical, effective, and easy for the masses to accept. It is suitable for routine screening and use at the grassroots level. The preliminary results show that the screening effect of this law is good and the benefits are high, which is expected to provide a new idea for the prevention and treatment of gastric cancer.