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1983年1月广州市区内报告首例流行性出血热(EHF)病人。我们以此例作为指示病例,于同年8～9月间开展了血清流行病学和疫源地调查,应用间接免疫荧光试验(IFAT)发现正常人隐性感染率为0.25％(1/395),查可疑病人血清6份,发现阳性1份,查非EHF病人血清11份,阳性1份(临床诊断可疑登革热病);褐家鼠肺脏带EHF病毒抗原阳性率为8.6％(48/555),其它小啮齿动物均未发现阳性,从而首次证实广州市存在EHF疫源地,其主要贮存宿主为褐家鼠。
January 1983 Guangzhou city report first case of epidemic hemorrhagic fever (EHF) patients. Using this case as an indicator case, we conducted a serological epidemiology and epidemic investigation from August to September of the same year. Indirect immunofluorescence test (IFAT) revealed that the rate of latent infection in normal people was 0.25% (1/395) , 6 cases of suspicious serum were found and 1 positive, 11 cases of non-EHF serum and 1 positive (clinical diagnosis of suspected dengue fever). The positive rate of EHF antigen in lungs of Rattus norvegicus was 8.6% (48/555) , No other small rodents were found positive, thus confirming the existence of EHF foci in Guangzhou for the first time, the main storage host Rattus norvegicus.