3例患者于2011年10月先后入院,因为不同疾病使用塞来昔布(200 mg,bid)后,分别于10、8、8 d后出现迟发型过敏反应,表现为重症多型性红斑,其中1例并发尿道口水肿、肝损害及心悸气短。停用塞来昔布并使用大剂量激素及对症支持治疗后,病情均不同程度好转。 Three patients were hospitalized in October 2011 because of delayed onset hypersensitivity reactions after 10, 8 and 8 days after treatment with celecoxib (200 mg bid) for different diseases, showing severe erythema multiforme, One case complicated urethral edema, liver damage and palpitations shortness of breath. After discontinuing celecoxib and using high-dose hormones and symptomatic supportive care, the condition improved to varying degrees.