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目的以卡托普利舌下含服治疗高血压急症，并与利血平肌注治疗对照。方法卡托普利３７．５ｍｇ舌下含服治疗高血压急症６０例为治疗组，６０例用利血平１．０ｍｇ肌注作对照。结果卡托普利组用药后１５ｍｉｎ即开始有显著的降压作用（Ｐ＜０．００１），３０，６０，１２０ｍｉｎ后疗效更显著（Ｐ＜０．００１）。对照组利血平用药后１５ｍｉｎ血压无显著下降（Ｐ＞０．０５），３０，６０，１２０ｍｉｎ血压明显下降（Ｐ＜０．００１）。二组比较，卡托普利组降压作用明显（Ｐ＜０．００１）。结论卡托普利舌下含服是治疗高血压急症较迅速、有效、安全、简便的降压方法，无明显不良反应
Objective To treat captopril sublingual hypertensive emergency, and with reserpine intramuscular treatment control. Methods Captopril 37.5mg sublingual treatment of acute stroke in 60 cases for the treatment group, 60 cases with reserpine 1.0mg intramuscular injection as a control. Results The captopril group began to have a significant antihypertensive effect (P <0.001) 15 min after treatment, and the effect was significant after 30, 60 and 120 min (P <0.001). No significant decrease in blood pressure was observed 15 min after administration of reserpine in the control group (P> 0.05), and blood pressure was significantly decreased at 30, 60 and 120 min (P <0.001). In the two groups, the antihypertensive effects of captopril group were significantly (P <0.001). Conclusions Captopril sublingual administration is a rapid, effective, safe and convenient antihypertensive treatment for hypertensive emergency without significant adverse reactions