目的 :观察新型人工肝分子吸附再循环系统(MARS)在慢性重型肝炎中的治疗作用 .方法 :对 7例常规治疗效果欠佳的慢性重型肝炎患者在原有治疗基础之上 ,加用MARS人工肝治疗 .结果 :加用MARS人工肝治疗之后 ,患者体内的血清总胆红质水平较治疗前迅速、明显下降 ,降幅达到9.2 %～ 5 9.7% ,但血清转氨酶、尿素氮、肌苷、白蛋白、胆固醇及凝血酶原时间无显著改变 ,治疗前后的外周血细胞成分及血清电解质浓度也无显著差别 .未发现严重的副作用及并发症 .结论 :在慢性重型肝炎的常规治疗中加用MARS人工肝可以显著降低患者体内以血清胆红质为代表的蛋白结合毒素 .MARS人工肝治疗对机体内环境影响较小 ,是一种安全有效的肝脏替代治疗方法 Objective: To observe the therapeutic effect of new artificial liver molecular adsorption and recirculation system (MARS) in chronic severe hepatitis.Methods: Seven patients with chronic severe hepatitis with poor routine treatment were treated with MARS artificial liver Treatment.Results: After adding MARS artificial liver, serum total bilirubin levels in patients’ serum were rapidly and obviously decreased by 9.2% -5.7%, but serum levels of aminotransferase, urea nitrogen, inosine and albumin , Cholesterol and prothrombin time did not change significantly, before and after treatment of peripheral blood cell components and serum electrolyte concentrations were also no significant difference.No serious side effects and complications.Conclusion: In the treatment of chronic severe hepatitis with MARS artificial liver Can significantly reduce the body of patients with serum bilirubin protein-binding toxins .MARS artificial liver therapy has little impact on the body environment, is a safe and effective liver replacement therapy