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目的:观察埃索美拉唑治疗胃食管反流病(GERD)的临床疗效。方法:将68例GERD患者随机分为两组:治疗组36例与对照组32例,治疗前进行症状(烧心、反酸和胸痛)分级评分与内镜检查分级,治疗8周后复查内镜并进行分级。结果:症状分级评分,治疗组缓解率91.66%,明显高于对照组缓解率71.87%,两组比较差异有显著性(P<0.05);内镜检查分级,治疗组治愈率88.88%,高于对照组78.12%,但两组比较差异无显著性(P>0.05),可能与观察例数过少有关。结论:埃索美拉唑治疗GERD,疗效优于奥美拉唑,是治疗GERD的理想的选择药物之一。
Objective: To observe the clinical efficacy of esomeprazole in the treatment of gastroesophageal reflux disease (GERD). Methods: Sixty-eight patients with GERD were randomly divided into two groups: 36 in the treatment group and 32 in the control group. The symptoms (heartburn, acid reflux and chest pain) were graded and endoscopically graded before treatment. And grading. Results: The symptom grade score was 91.66% in the treatment group, which was significantly higher than 71.87% in the control group (P <0.05). The grade of the endoscopic examination was 88.88% in the treatment group, which was higher than The control group 78.12%, but there was no significant difference between the two groups (P> 0.05), may be related to the number of observations less. Conclusion: Esomeprazole is superior to omeprazole in the treatment of GERD and is one of the ideal choice drugs for the treatment of GERD.