目的 :探讨孕前优生健康检查高风险人群评估指导意义。方法 :对2015年1月-2016年1月接受654例孕前优生健康检查者进行病史询问、男女双方体格检查、实验室检查、病毒筛查、妇科超声检查、风险评估和咨询指导。结果 :654例患者中以20-40岁居多。初婚未育者478例,所占比例为73.1%,已生育者176例,所占比例为26.9%;有遗传性疾病史或近亲婚配史的2例,所占比例为0.3%;有分娩过出生缺陷儿12例,所占比例为1.8%。男性的不良接触史主要为饮酒和吸烟,女性的不良接触史主要为吸烟和饲养宠物。大三阳检出者23例;小三阳伴肝功能损害22例;风疹病毒Ig G阳性2例;巨细胞病毒Ig M阳性1例;弓形体Ig M阳性1例;梅毒螺旋体阳性2例;甲状腺功能异常5例;血糖异常9例;血型不合有12例;女性中度贫血有3例%。结论 :孕前保健中发现的绝大部分危害生殖健康的因素可以通过孕前健康教育和检查而避免,并且重视孕前保健及生殖健康有利于提高人口素质。 Objective: To explore the significance of pre-pregnancy eugenics in assessing the risk of high-risk population. Methods: From January 2015 to January 2016, 654 pregnant women with prenatal eugenics were examined by medical history, physical examination of both sexes, laboratory examination, virus screening, gynecological ultrasonography, risk assessment and counseling. Results: Most of the 654 patients were aged 20-40. There were 478 cases of first infertility, accounting for 73.1% of all cases, 176 cases of infertile children, accounting for 26.9%; 2 cases had history of genetic disease or marriage of inces, accounting for 0.3%; those with childbirth 12 cases of birth defects, accounting for 1.8%. The history of adverse male exposure is mainly alcohol and smoking. The history of adverse female exposure is mainly smoking and keeping pets. 23 cases were diagnosed as Sanyangang, 22 cases were diagnosed as Sanyang with liver dysfunction, 2 cases were Ig G positive for rubella virus, 1 case was positive for cytomegalovirus Ig M, 1 case was IgM positive for Toxoplasma gondii, 2 cases were positive for Treponema pallidum, 2 cases were thyroid 5 cases of abnormal function; 9 cases of abnormal blood glucose; 12 cases of blood group incompatibility; 3 cases of female moderate anemia. CONCLUSIONS: Most of the factors that are harmful to reproductive health found in prenatal care can be avoided through pre-pregnancy health education and examination. Emphasis on prenatal care and reproductive health is conducive to improving the quality of the population.