Emerging and reemerging human-infecting viruses have been repre-senting a massive threat to public health and have raised global concerns in recent years [1,2].While scientists and the public have worried and pre-pared for the emerging influenza-induced pandemic,the recognized first coronavirus caused pandemic raided the humans.As the new disease's eti-ology recognized as coronavirus disease 2019 (COVID-19),severe acute re-spiratory syndrome coronavirus-2 (SARS-CoV-2) has spread throughout the world in a few months since late 2019 and thus far has caused more than 50 million infections with over 1 million deaths.In front of this severe and complicated new infectious disease,many countries,including China,have well-controlled the domestic transmission of COVID-19,based on pos-itive attitudes,practical strategies,and scientific measures.The two primary forefronts in combating the new virus are epidemiological inter-vention and laboratory investigation.The field surveillance and interven-tion strategies comprise the origin tracing,the transmission route investigation,quarantine of the contacts,and other epidemiological emer-gency disposals.The laboratory activities involve studies on the diagnostic agents,drug and vaccine development,viral pathogenesis,and host immu-nity.Meanwhile,biosafety is unanimously recognized as the most crucial issue in safeguarding these processes.This thematic issue is dedicated to the most recent studies covering these strategies,which may provide recommendations for controlling COVID-19.