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系统性红斑狼疮(SLE)是自身免疫病。累及多种器官系统而表现不同的临床症状,如皮肤病损、发热、肺炎、贫血以及损害关节、心、肾及其它脏器。以生育年龄黑种妇女最多见。1971年美国风湿病学会(ARA)制订了系统性红斑狼疮的诊断标准,1982年加以修订,在11项指标中须占有4项以上才能诊断。11项指标如下:颧骨部位皮疹、盘状皮疹、光致敏性、口腔溃疡、关节炎、浆膜炎、肾病损、神经系统病变、血液病变、免疫功能异常和抗核抗体。其中免疫功能异常包括检出红斑狼疮(LE)细胞、抗DNA抗体、抗天然DNA(n-DNA)抗体、抗-Sm抗体等。红斑狼疮侵及肾引起肾炎预后不良,但系统性红斑狼疮在今天10年生存率已接近90%。早期诊断并给予积极治疗预后愈佳。
Systemic lupus erythematosus (SLE) is an autoimmune disease. Involving a variety of organ systems and the performance of different clinical symptoms, such as skin lesions, fever, pneumonia, anemia and damage to joints, heart, kidney and other organs. Black women of childbearing age most see. 1971 The American College of Rheumatology (ARA) developed a diagnostic criteria for systemic lupus erythematosus, revised in 1982, in 11 indicators to take more than 4 to be diagnosed. Eleven indicators were as follows: zygomatic rash, discoid rash, photo-sensitization, mouth ulcers, arthritis, serositis, nephropathy, neurological disorders, blood disorders, immunodeficiency and antinuclear antibodies. Immunological abnormalities include detection of lupus erythematosus (LE) cells, anti-DNA antibodies, anti-natural DNA (n-DNA) antibodies, anti-Sm antibodies and the like. Lupus erythematosus and nephritis invading renal adverse prognosis, but 10-year systemic lupus erythematosus survival rate has been close to 90%. Early diagnosis and give positive treatment better prognosis.