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菊蒿(Tanacetum parthenium,Feverfew)是一种常用的药用植物,在传统医学中用于治疗偏头痛。现代临床试验证明菊蒿能够减轻偏头痛的程度和降低发作的频率,药理学研究发现它能抑制血小板的聚集,抑制血小板释放5-羟色胺和抑制巨噬细胞释放组胺等。菊蒿的主要成分为parthenolide(Pa),是一种倍半萜内酯。据报道它是许多倍半萜内酯化合物中,抑制5-羟色胺释放活性最强的化合物,并能抑制PTK和PKC。本次采用小鼠纤维肉瘤细胞系(MN-11)和人淋巴瘤细胞系
Artemisia (Tanacetum parthenium, Feverfew) is a commonly used medicinal plant used in the treatment of migraine in traditional medicine. Modern clinical trials have demonstrated that Artemisia can reduce the degree of migraine and reduce the frequency of episodes. Pharmacological studies have found that it can inhibit platelet aggregation, inhibit platelet release of serotonin, and inhibit the release of histamine from macrophages. The main component of Artemisia annua is parthenolide (Pa), which is a sesquiterpene lactone. It is reported that it is a compound that inhibits serotonin release activity most in many sesquiterpene lactone compounds and can inhibit PTK and PKC. The mouse fibrosarcoma cell line (MN-11) and human lymphoma cell line were used this time.