扁平苔癣的组织学特点是上皮缺陷,近来的研究表明,可能存在对基底细胞层内抗原性改变的细胞免疫反应。对基底细胞的抗原性影响,可能是由于外在或内在的刺激,因而是变态反应性或自体免疫源的。扁平苔癣受侵上皮细胞的组织学和生化学研究,也显示酶活性异常和糖类代谢的缺陷,这可能同主要参与代谢过程的激素有关。如今认为至少依赖胰岛素的糖尿病与免 Histopathology of lichen planus is characterized by epithelial defects. Recent studies have shown that there may be a cellular immune response to antigenic changes in the basal cell layer. The antigenic effects on basal cells may be due to extrinsic or intrinsic stimuli and thus to allergic or autoimmune sources. Histological and biochemical studies of epithelial cells affected by lichen planus also show abnormal enzyme activity and defects in carbohydrate metabolism, which may be related to hormones that are mainly involved in metabolic processes. Now think that at least insulin dependent diabetes and free