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目的:探讨汉族人群中血清铁蛋白水平与2型糖尿病(type 2 diabetes mellitus,T2DM)间的相关性。方法:分别测定400例T2DM患者(T2DM组)、400例高血清铁蛋白非糖尿病(non-diabetes mellitus,NDM组)患者和400名健康体检人群(正常对照组)的空腹胰岛素、血清铁蛋白和血细胞分析(血红蛋白、血细胞比容、平均红细胞体积、平均血红蛋白)等指标。结果:空腹胰岛素指标在T2DM组与NDM组、健康对照组间差异有统计学意义(P<0.001);血清铁蛋白、血细胞比容、血红蛋白、平均红细胞体积等指标在T2DM组、NDM组及健康对照组两两之间差异存在统计学意义(P<0.001)。当T2DM患者的血清铁蛋白水平>292.5 mg/L时,其诊断T2DM的灵敏度和特异度分别为55.2%和91.6%,曲线下面积为0.82,血清铁蛋白与血细胞比容、血红蛋白及平均红细胞体积等指标相比,显示出与疾病间更好的风险关系。结论:血清铁蛋白水平升高与T2DM的高风险相关。
Objective: To investigate the relationship between serum ferritin level and type 2 diabetes mellitus (T2DM) in Han population. Methods: The levels of fasting insulin, serum ferritin, and serum ferritin in 400 T2DM patients (T2DM group), 400 patients with non-diabetes mellitus (NDM group) and 400 healthy controls (normal control group) Blood cell analysis (hemoglobin, hematocrit, mean corpuscular volume, mean hemoglobin) and other indicators. Results: There was a significant difference in fasting insulin between T2DM group and NDM group and healthy control group (P <0.001). The levels of serum ferritin, hematocrit, hemoglobin and mean erythrocyte volume in T2DM group, NDM group and healthy The difference between the two groups in the control group was statistically significant (P <0.001). The sensitivity and specificity of T2DM in diagnosing T2DM were 55.2% and 91.6% respectively when the serum ferritin level was> 292.5 mg / L in T2DM patients. The area under the curve was 0.82. Serum ferritin, hematocrit, hemoglobin and mean corpuscular volume And other indicators, compared with the disease showed a better risk relationship. Conclusions: Elevated serum ferritin levels are associated with a high risk of T2DM.