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目的观察盐酸吉西他滨联合奈达铂治疗晚期非小细胞肺癌的近期疗效和毒副反应。方法核工业部四一六医院肿瘤科收治的有病理学依据的30例晚期非小细胞肺癌患者给予盐酸吉西他滨联合奈达铂化疗:给予吉西他滨1000 mg/m2,第1、8天,奈达铂80 mg/m2,第l天,同时给予常规止吐治疗,3周重复1次。2个周期后评价疗效和毒性。结果全组30例均可评价疗效,其中完全缓解(CR)1例,部分缓解(PR)10例,无变化(NC)13例,进展(PD)6例,总有效率(CR+PR)36.66%。毒副反应主要是轻度恶心呕吐,无Ⅲ~Ⅳ度恶心呕吐发生,骨髓抑制轻,Ⅰ~Ⅱ度骨髓抑制16例,Ⅲ度骨髓抑制2例,无Ⅳ度骨髓抑制发生。无显著心脏,肝肾功能损害。结论吉西他滨联合奈达铂治疗晚期非小细胞肺癌有疗效较好,毒副反应较轻,值得临床推广使用。
Objective To observe the short-term curative effect and toxicity of gemcitabine hydrochloride combined with nedaplatin in the treatment of advanced non-small cell lung cancer. Methods Thirty patients with advanced non-small cell lung cancer who were admitted to Department of Oncology, 416 Hospital of Nuclear Industry, Department of Oncology were given gemcitabine hydrochloride combined with nedaplatin chemotherapy: gemcitabine 1000 mg / m 2, days 1 and 8, nedaplatin 80 mg / m2, the first day, while giving conventional antiemetic treatment, 3 weeks repeated 1 time. After 2 cycles evaluation of efficacy and toxicity. Results The complete response rate (CR), one case of complete remission (CR), 10 cases of partial remission (PR), 13 cases of no change (NC) and 6 cases of progression (PD) 36.66%. The main side effects were mild nausea and vomiting, nausea and vomiting without grade Ⅲ ~ Ⅳ, mild myelosuppression, 16 cases with Ⅰ ~ Ⅱ degree myelosuppression, 2 cases with Ⅲ degree myelosuppression, and no Ⅳ degree myelosuppression. No significant heart, liver and kidney dysfunction. Conclusion Gemcitabine combined with nedaplatin in the treatment of advanced non-small cell lung cancer has better curative effect and less toxic side effects, which is worthy of clinical promotion.