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目的观察放疗联合顺铂加氟尿嘧啶(PF)化疗方案治疗非手术食管癌的临床疗效。方法 66例非手术食管癌患者随机分为2组:同步放化组(同步组)33例,序贯放化组(序贯组)33例。放疗为6MVX线三维适形,治疗剂量60 Gy,6 wk完成。化疗方案:序贯组给予顺铂30 mg.m-2.d-1,iv,d 1～3;氟尿嘧啶700 mg.m-2.d-1,iv,d 1～5,28 d为一个周期。同步组给予顺铂20 mg.m-2.d-1,iv,d 1～3;氟尿嘧啶600 mg.m-2.d-1,iv,d 1～4,28 d为一个周期与放疗同步进行。2组化疗均为4个疗程。结果同步组、序贯组近期有效率(显效+有效)分别为94%(31/33)和76%(25/33),1、3、5年生存率分别是86%、61%、30%和69%、24%、13%;2组间均有显著差异(P<0.05)。结论 PF化疗方案联合放疗同步治疗非手术食管癌可以提高近期疗效和远期生存率。
Objective To observe the clinical efficacy of radiotherapy combined with cisplatin plus fluorouracil (PF) chemotherapy in the treatment of non-surgical esophageal cancer. Methods Sixty-six patients with non-surgical esophageal cancer were randomly divided into two groups: 33 patients in synchronized radiotherapy group (synchronous group) and 33 patients in sequential radiotherapy group (sequential group). Radiotherapy for 6MVX line three-dimensional conformal, the treatment dose of 60 Gy, 6 wk completed. Chemotherapy: sequential group given cisplatin 30 mg.m-2.d-1, iv, d 1 ~ 3; fluorouracil 700 mg.m-2.d-1, iv, d 1 ~ 5,28 d as a cycle. Synchronous group was given cisplatin 20 mg.m-2.d-1, iv, d 1 ~ 3; fluorouracil 600 mg.m-2.d-1, iv, d 1 ~ 4, get on. 2 groups of chemotherapy are 4 courses. Results The results showed that the effective rate (effective rate) of the sequential group was 94% (31/33) and 76% (25/33) respectively, and the 1,3 and 5 year survival rates were 86%, 61% and 30% % And 69%, 24% and 13%, respectively. There was significant difference between the two groups (P <0.05). Conclusion PF chemotherapy combined with radiotherapy in the treatment of non-surgical esophageal cancer can improve the short-term efficacy and long-term survival rate.