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自然杀伤细胞(NK)是日渐为人们所重视的一类免疫细胞,研究认为NK细胞更重要的功能是作为造血细胞和淋巴细胞的调节细胞在维持免疫反应的自身稳定中起主要作用,在形态学上NK细胞属于大颗粒淋巴细胞(LGL)的一种,在一些疾病中NK细胞活性随着LGL数目的变化而变化,还有的学者尝试将末梢血中LGL数目作为判断LGL功能的指标,LGL计数能否反映NK的活性,能否以计数外周血的LGL数来作为观察NK活性的一种简便易行的方法?从1990～1992年本室做了这类工作。
Natural killer (NK) cells are a type of immune cells that are increasingly valued. Studies have suggested that the more important function of NK cells is that they play a major role in maintaining the self-stability of the immune response as regulatory cells for hematopoietic and lymphoid cells. NK cells belong to the class of large granulocyte lymphocytes (LGL). In some diseases, the activity of NK cells varies with the number of LGL. Some scholars try to determine the number of LGL in peripheral blood as an indicator of the function of LGL. Can LGL count reflect the activity of NK? Is it possible to count the number of LGL in peripheral blood as an easy and convenient way to observe NK activity? From 1990 to 1992, we did such work.