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本研究的目的是为了阐明心耳切除术如何影响衰竭心脏的血液动力状况和心房利钠多肽(ANP)的分泌功能。采用11条杂种犬,在股动、静脉之间人工造成动静脉瘘,制备出高排心衰模型。在此手术后2个月,5条犬切除双侧心耳,观察其对基础和起搏诱导心房利钠多肽分泌的影响,同时测量多项血液动力学指标。其余6条犬做为对照组,同样起搏诱导心房利钠多肽分泌,检测方法同前组。在心耳切除后,收缩血压和心房压均无变化,但血浆ANP水平降低(292±54至188±47pg/ml,P<0.01),心排量减少(3.7±0.9至3.0±0.8L/min,P<0.01)。在起搏诱导心动过速期间,尽管两组左心房压力相
The purpose of this study was to elucidate how aurotomy affects the hemodynamic status of failing heart and the secretory function of atrial natriuretic peptide (ANP). Using 11 mongrel dogs, artificial femoral arteriovenous fistula was established between the femoral and venous arteries, and a model of heart failure was prepared. At 2 months after the operation, the bilateral atrial appendices were resected in 5 dogs, and their effects on basal and pacing-induced atrial natriuretic peptide secretion were observed. A number of hemodynamic parameters were also measured. The remaining six dogs as a control group, the same pacemaker induced atrial natriuretic peptide secretion, detection methods with the previous group. There was no change in systolic blood pressure and atrial pressure after atrial appendage resection, but plasma ANP levels decreased (292 ± 54 to 188 ± 47 pg / ml, P <0.01) and cardiac output decreased (3.7 ± 0.9 to 3.0 ± 0.8 L / min , P <0.01). During pacing-induced tachycardia, both left atrial pressure phases