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目的观察T2DM伴慢性牙周炎在降血糖治疗的基础上加用牙周炎治疗的临床效果。方法 T2DM伴慢性牙周炎患者120例随机分为治疗组和对照组,对照组采用常规降糖治疗,治疗组在对照组的基础上加用牙周基础治疗。比较两组治疗前与治疗6周后各项指标。结果两组治疗前牙周袋探诊深度(PD)、附着丧失(AL)、菌斑指数(PLI)、牙龈出血指数(BI)、高敏C反应蛋白(hsC-RP)水平比较差异无统计学意义(P>0.05)。治疗组治疗后PD、AL、PLI、BI、hsC-RP较治疗前及对照组降低[PD:(2.51±0.68),(2.42±0.31)vs(2.11±0.28)mm;AL:(3.58±0.83),(3.49±0.58)vs(3.18±0.41)mm;PLI:(0.96±0.33),(0.78±0.26)vs(0.41±0.21);BI:(2.65±1.21),(1.14±0.30)vs(0.97±0.32);hsC-RP:(3.29±2.88),(2.72±1.51)vs(1.02±0.63)mg/L](P<0.05)。结论 T2DM伴慢性牙周炎在降糖治疗的基础上加用牙周炎治疗可减少炎性因子水平。
Objective To observe the clinical effect of adding periodontitis on the basis of hypoglycemic treatment of T2DM with chronic periodontitis. Methods 120 cases of T2DM with chronic periodontitis were randomly divided into treatment group and control group. The control group was given routine hypoglycemic treatment. The treatment group was treated with periodontal basis on the basis of the control group. The indexes before treatment and after 6 weeks of treatment were compared between the two groups. Results There was no significant difference in probing depth (PD), attachment loss (AL), plaque index (PLI), gingival bleeding index (BI) and hsC-RP between the two groups before treatment Significance (P> 0.05). The levels of PD, AL, PLI, BI and hsC-RP in the treatment group were significantly lower than those before treatment and in the control group [PD: 2.51 ± 0.68 vs 2.42 ± 0.31 vs 2.11 ± 0.28, AL: 3.58 ± 0.83 (3.49 ± 0.58) vs (3.18 ± 0.41) mm; PLI: (0.96 ± 0.33), (0.78 ± 0.26) vs (0.41 ± 0.21); BI: (2.65 ± 1.21) 0.97 ± 0.32); hsC-RP: (3.29 ± 2.88), (2.72 ± 1.51) vs (1.02 ± 0.63) mg / L] (P <0.05). Conclusion T2DM with chronic periodontitis on the basis of hypoglycemic treatment combined with periodontitis can reduce the level of inflammatory cytokines.