论文部分内容阅读
成人呼吸窘迫综合征(ARDS)是由于肺内中性白细胞积聚所致的肺功能紊乱。中性白细胞聚集的机制与补体系统相关,当补体系统激活时,补体C_(5a)形成,趋化吸引中性白细胞。但此趋化作用可被趋化灭活因子(CFI)降低.而ARDS 肺内,CFI 机能缺失致使C_(5a)活性增高,中性白细胞增多.这些细胞聚集在肺内,通过释放毒性氧化代谢物和蛋白酶,引发和维持肺水肿,形成以低氧血症为特征的肺功能紊乱.
Adult respiratory distress syndrome (ARDS) is a disorder of the lung due to accumulation of neutrophils in the lungs. The mechanism of neutrophil aggregation is related to the complement system. When the complement system is activated, complement C_ (5a) forms and chemotaxis attracts neutrophils. However, this chemoattractant may be reduced by chemotactic inactivation factor (CFI), whereas in ARDS, the absence of CFI results in an increase in C_ (5a) activity and an increase in neutrophils, which accumulate in the lungs and release toxic oxidative metabolism And proteases, triggering and maintaining pulmonary edema, resulting in pulmonary dysfunction characterized by hypoxemia.