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阻断臂动脉诱发的血流介导的血管舒张反应是评估NO依赖性内皮功能的有效指标,但这种血管舒张反应在2型糖尿病患者中受到损伤。西地那非是5-磷酸二酯酶抑制剂,适用于多种病因的ED患者,包括2型糖尿病患者。但西地那非对于这类患者血管内皮功能的影响还没有实验进行评估。为此Desouza C等进行了一项双盲、安慰剂对照的临床试验,评估小剂量西地那非(25mg)对于2型糖尿病患者血流介导的血管舒张反应的即刻和长期效应。共入选16名2型糖尿病患者(其中14名患者完成本试验),并且没有明显的心脏病。患者的臂动脉平均直径为4．33+／-0．6mm,在诱发血流介导的血管舒张反应后,平均臂动脉
Blocking the arterial-induced blood flow-mediated vasodilation is a valid measure of NO-dependent endothelial function, but this vasodilatation is impaired in patients with type 2 diabetes. Sildenafil is a 5-phosphodiesterase inhibitor for ED patients with multiple etiologies, including type 2 diabetes. However, the effects of sildenafil on vascular endothelial function in these patients have not been evaluated experimentally. To this end, Desouza C et al conducted a double-blind, placebo-controlled clinical trial to evaluate the immediate and long-term effects of low-dose sildenafil (25 mg) on blood-mediated vasorelaxation in patients with type 2 diabetes. Sixteen patients with type 2 diabetes (14 of whom completed the trial) were enrolled and did not have any significant heart disease. The average arm artery diameter was 4.33 +/- 0.6 mm. After inducing a flow-mediated vasodilation, the average arm artery