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目的 探讨LT β在SLE患者免疫调节紊乱中的作用 .方法 PBLRNA斑点杂交测定LT β基因转录水平 ;PCR RLFP法分析LT β基因多态性 .结果 SLE中LT β基因转录比正常对照显著增高 (P <0 .0 5 ) .未发现LT β基因的XhoⅠ酶切位点具有多态性 .结论 提示LT β参与SLE的免疫调节紊乱 .
OBJECTIVE: To investigate the role of LTβ in the regulation of immunoregulation in SLE patients.Methods Transcription level of LTβ was detected by PBLRNA blotting and LTβ gene polymorphism was analyzed by PCR-RLFP method.Results The transcription of LTβ gene in SLE was significantly higher than that of normal control (P <0.05) .There was no polymorphism in the Xho Ⅰ restriction site of LT β gene.Conclusions suggest that LT β is involved in the disorder of immune regulation of SLE.