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获得移植物特异性的免疫耐受是同种异型移植的最终目标。调节性细胞的主动免疫抑制作用是诱导外周耐受的主要机制之一。CD4+ CD25+调节性T细胞作为一种调节性T细胞亚类,它所介导的免疫抑制在移植耐受的诱导和维持中起关键作用。本文就CD4+ CD25+ 调节性T细胞在移植耐受中的调节
Acquired graft-specific immune tolerance is the ultimate goal of allogeneic transplantation. Active immunosuppression of regulatory cells is one of the major mechanisms that induce peripheral tolerance. As a subset of regulatory T cells, CD4 + CD25 + regulatory T cells play a key role in the induction and maintenance of transplant tolerance mediated by immunosuppression. In this paper, the regulation of CD4 + CD25 + regulatory T cells in transplant tolerance