论文部分内容阅读
为了观察围术期应用可乐定透皮制剂对术后病人自控镇痛（ＰＣＡ）的影响，将试验设计为随机、双盲的对照研究。６０例腹部手术患者随机分为两组，术前两日上臂贴安慰剂贴剂或可乐定透皮制剂２贴（每贴２．５ｍｇ），术后病人自控吗啡镇痛７２ｈ。评定术后吗啡用量、疼痛、镇静、焦虑水平，对血流动力学的影响及恶心、呕吐等药物不良反应。分别在麻醉前、手术完毕及术后一日取静脉血，测定血浆肾素、血管紧张素、醛固酮水平。结果表明可乐定组患者病人自控镇痛吗啡用量减少，镇静增强，焦虑水平降低，血流动力学及应激激素稳定。结论为可乐定透皮制剂有助于病人自控镇痛的实施。
To examine the effect of perioperative clonidine transdermal delivery on postoperative patient-controlled analgesia (PCA), the trial was designed as a randomized, double-blind, controlled study. Sixty patients undergoing abdominal surgery were randomly divided into two groups. Patients were given morphine analgesia for 72 hours after surgery. Assessment of postoperative morphine dosage, pain, sedation, anxiety levels, hemodynamic effects and nausea, vomiting and other adverse drug reactions. Venous blood was taken before anesthesia, at the end of surgery and one day after operation, respectively. Plasma renin, angiotensin and aldosterone levels were measured. The results showed that clonidine patients with controlled analgesic analgesic use of morphine reduced sedation increased anxiety levels decreased hemodynamics and stress hormone stability. The conclusion is that clonidine transdermal preparation is helpful for the implementation of patient controlled analgesia.