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目的 :探讨肝血管平滑肌脂肪瘤的临床病理学特点、诊断和鉴别诊断要点。方法 :复习 10例肝血管平滑肌脂肪瘤 (Aml)临床资料 ,并用石蜡切片进行组织化学、免疫组化检测 ,2例进行电镜观察。结果 :10例Aml中 8例女性 ,2例男性 ,平均年龄44岁。临床无症状 ,而是影像学检查偶然发现。大体上为境界清楚但无包膜的肿块。光镜下由 3种成分即厚壁血管、上皮样或梭形平滑肌细胞及脂肪混合组成 ,偶尔还可见髓外造血成分。免疫组化检查瘤细胞表达A10 3、HMB45及平滑肌标记。结论 :Aml组织学形态变化多样 ,3种主要成分的比例和分布各异。检测A10 3和HMB45有助于确诊。
Objective: To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of hepatic angiomyolipoma. METHODS: Clinical data of 10 cases of hepatic angiomyolipoma (Aml) were reviewed. Paraffin sections were used for histochemical and immunohistochemical detection. Two cases underwent electron microscopy. RESULTS: Of the 10 cases of Aml, 8 were female and 2 were male, with an average age of 44 years. Clinically asymptomatic, but imaging findings were found by chance. It is generally a clear but non-enveloped mass. Light microscopy consists of three components, namely thick-walled blood vessels, epithelioid or fusiform smooth muscle cells, and a mixture of fat, and occasionally extramedullary hematopoietic components are also seen. Immunohistochemical examination of tumor cells expressed A10 3, HMB45 and smooth muscle markers. Conclusion: The histological changes of Aml are various, and the proportion and distribution of the three main components are different. Detection of A10 3 and HMB45 helps confirm the diagnosis.