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1965年Pickle首先用生物学方法测定了子宫内膜及经血中的前列腺素(PGs)水平,发现其水平增高与痛经和子宫出血有关,引起了很多学者的关注。70年代后,由于出现气相色谱、放射免疫等更精确的测定方法,大大促进了这方面的研究工作。本文简要综述近年来对子宫PGs水平影响月经血量研究的有关问题。一、PGs简介 PGs是一组化学结构相似、具有生理活性的不饱和羟基脂肪酸。它广泛存在于人和哺乳动物的组织和体液中,含量极微而效应很强,不同类型的PG因结构上微小的差异可表现不同的生理活性。由于PGs不是由特定的内分泌腺产生,无特异的促激素,在血
In 1965, Pickle first used biological methods to determine the level of prostaglandins (PGs) in endometrium and menstrual blood. It was found that the increased levels of PGs were associated with dysmenorrhea and uterine bleeding, which attracted many scholars’ attention. After the 1970s, due to the emergence of gas chromatography, radioimmunoassay and other more accurate determination of methods, greatly contributed to this research. This article briefly summarizes the recent years on the level of uterine PGs affect menstrual blood related issues. First, PGs Introduction PGs is a group of chemically similar, with physiological activity of unsaturated hydroxy fatty acids. It is widely present in human and mammalian tissues and body fluids with minimal and high effects. Different types of PG show different physiological activities because of their structurally small differences. Since PGs are not produced by specific endocrine glands, there are no specific pro-hormones in the blood