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目的 通过监测分析 ,掌握全省肾综合征出血热 (HFRS)流行规律 ,控制暴发流行 ,进一步降低发病率 ,制订防制措施。方法 采用直接免疫荧光法 (FAT)检测鼠肺HV抗原 ;采用间接免疫荧光法 (IFAT)检测HFRS病人、健康人血清。结果 1995～ 2 0 0 0年全省共发病 96 188例 ,年均发病率为 18 36 /10万 ,死亡 345人 ,病死率为 0 36 %。病例仍主要分布在鲁中南山区和胶莱平原 ,鲁西北平原次之 ,鲁东南丘陵地区病例较少 ;全省 17个地市 137个县有病例报告 ,以鲁中南山区和胶莱平原的临沂、日照、济南、淄博和潍坊 5市发病最多 ,占全省病例总数的 6 2 2 4 %。宿主动物野外以褐家鼠和黑线姬鼠为优势种 ,分别占 4 0 4 4 %和 33 75 % ;室内以褐家鼠为优势种 ,占 82 0 8%。结论 进一步加大监测力度及接种HFRS疫苗 ,是控制该病的有效措施
Objective To monitor and analyze the prevalence of hemorrhagic fever with renal syndrome (HFRS) in the province, control the outbreak of epidemics, further reduce the morbidity and make prevention measures. Methods The mouse lung HV antigen was detected by direct immunofluorescence (FAT), and the serum of HFRS patients and healthy people was detected by indirect immunofluorescence assay (IFAT). Results From 1995 to 2000, a total of 96 188 cases were found in the province, with an average annual incidence of 18 36/10 million, 345 deaths and a case fatality rate of 0 36%. The cases are still mainly distributed in the mountainous areas of Central and Southern Shandong and the Jiaolai Plain, followed by the northwest of Shandong Province and less in the hilly areas of southeastern Shandong Province. There are 137 case reports in 137 cities of 17 provinces in the province, with Linyi Rizhao, Jinan, Zibo and Weifang have the most incidences, accounting for 62.4% of the total cases in the province. The dominant species of host animals were Rattus norvegicus and Apodemus agrarius, accounting for 44.4% and 33.5%, respectively. The dominant species was Rattus norvegicus, accounting for 82.8% of the total. Conclusions To further increase monitoring and vaccination of HFRS vaccine is an effective measure to control the disease