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目的探讨新疆地区汉族人群非酒精性脂肪肝(NAFLD)合并高血压的危险因素。方法收集新疆医科大学第一附属医院新入院治疗诊治的400例非糖尿病NAFLD患者,根据是否合并高血压分为单纯NAFLD组200例,高血压+NAFLD组200例,同时选取200例健康对照组,采用问卷调查方法收集研究对象家族史、吸烟史、身高、体重、腰围、臀围、体质指数(BMI)、血压、空腹血糖、肝肾功能、血脂等指标,采用logistic回归分析NAFLD发生的相关危险因素。结果高血压+NAFLD组患者腰围(WC)、腰臀比(WHR)、舒张压(DBP)、收缩压(SBP)、BMI、甘油三酯(TG)、尿酸(UA)较单纯NAFLD组高,差异有统计学意义(P<0.01或P<0.05)。Logistic回归分析结果显示,BMI(OR=1.384,95%CDCI 1.215~1.570)、TG(OR=1.437,95%CI 1.024~2.018)、UA(OR=12.98,95%CI 1.450~3.410)对NAFLD合并高血压的发生有显著影响(均P<0.01)。结论 NAFLD合并高血压易发生于肥胖、血脂紊乱人群,BMI、TG、UA是NAFLD合并高血压的主要危险因素。适当减轻体重,控制脂肪代谢紊乱,有助于减少NAFLD的发生和延缓疾病的进展。
Objective To investigate the risk factors of non-alcoholic fatty liver disease (NAFLD) with hypertension in Han nationality in Xinjiang region. Methods 400 cases of non-diabetic NAFLD patients admitted to the First Affiliated Hospital of Xinjiang Medical University for treatment were divided into two groups: 200 cases of NAFLD and 200 cases of NAFLD and 200 cases of NAFLD. Family history, smoking history, height, weight, waist circumference, hip circumference, body mass index (BMI), blood pressure, fasting blood glucose, liver and kidney function and blood lipid were collected by questionnaire. Logistic regression was used to analyze the related risk of NAFLD factor. Results Compared with NAFLD group, the WC, WHR, DBP, SBP, BMI, triglyceride and uric acid in hypertensive + NAFLD group were significantly higher than those in NAFLD group The difference was statistically significant (P <0.01 or P <0.05). Logistic regression analysis showed that NAFLD was combined with BMI (OR = 1.384, 95% CDCI 1.215-1.570), TG (OR = 1.437, 95% CI 1.024-2.018) and UA (OR = 12.98, 95% CI 1.450-3.410) Hypertension occurred significantly (both P <0.01). Conclusions NAFLD complicated with hypertension is easy to occur in obesity, dyslipidemia, BMI, TG and UA are the main risk factors of NAFLD complicated with hypertension. Appropriate to reduce weight, control fat metabolism disorders, help to reduce the occurrence of NAFLD and delay the progress of the disease.