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本文对１３９例孕早期用药妇女的人胚绒毛细胞染色体诱变性进行了分析。在用药的种类上着重分析了抗菌素、激素，磺胺等类药物对人胚绒毛细胞的诱变作用，研究结果说明：这几类药物对孕早期人胚绒毛细胞染色体有明显的诱变作用。用药组染色体的诱变率高于未用药组。药物的种类不同，诱变的程度与对染色体诱变作用的类型也不同。磺胺类药物对观察的各项指标均有明显的影响，而激素类药物对人胚绒毛细胞微核影响大于其它类药物，是未用药组的６倍以上。通过研究我们认为：孕期用药必须十分慎重，宜采用最小有效剂量，尤其是在孕早期器官形成阶段。
Chromosome mutagenesis of human embryo villi in 139 pregnant women in the first trimester was analyzed in this paper. In the type of medication, the mutagenic effects of antibiotics, hormones, sulfonamides and other drugs on human embryo villus cells are analyzed emphatically. The results show that these drugs have significant mutagenic effects on the chromosomes of human embryo villus cells in early pregnancy. The mutation rate of the chromosomes in the treatment group was higher than that of the untreated group. Different types of drugs, the extent of mutagenesis and the role of chromosomal mutation are also different types. Sulfa drugs on the observed indicators have a significant impact, and hormone drugs on the human micronuclei of human hair cells more than other drugs, is not used more than 6 times. Through research, we believe that: medication during pregnancy must be very careful, the minimum effective dose should be used, especially in the early stages of organ formation.