混合性结缔组织病在儿童少见,合并无菌性脑膜炎在成人已有报告,但儿童近年来尚未见报告,现报告1例如下: 患儿 女,9岁。间断前额痛半年,持续发热10天,体温波动时头疼加重,偶有呕吐。入院前8个月起遇冷后发作性指(趾)苍白,继之青紫及潮红,且有一过性关节疼痛。无异常家族史。查体:体温38.5℃,发育正常,肢端凉,双手指皮肤苍白,软组织肿胀。颈部抵抗,双肺、心脏及腹部未见异常。右侧巴氏征(+),肌张力略增强,入院后临床观察多次出现雷诺氏现象。实验室检查:血红蛋白126g/L,白细胞7.1×10~9/L,血小板268×10~9/L,血沉29mm/h。血 Mixed connective tissue disease is rare in children, with aseptic meningitis has been reported in adults, but children have not been reported in recent years, a report is as follows: Children, 9 years old. Intermittent forehead pain for six months, sustained fever for 10 days, headache increased body temperature fluctuations occasionally vomiting. Eight months before admission, onset of cold fingers (toes) pale, followed by bruising and flushing, and had a sexual joint pain. No abnormal family history. Physical examination: body temperature 38.5 ℃, normal development, cold extremities, fingers pale skin, soft tissue swelling. Neck resistance, lungs, heart and abdomen no abnormalities. The right side of the Pakistan’s sign (+), muscle tone increased slightly after admission, clinical observation Raynaud’s phenomenon many times. Laboratory tests: hemoglobin 126g / L, white blood cells 7.1 × 10 ~ 9 / L, platelets 268 × 10 ~ 9 / L, ESR 29mm / h. blood