红细胞膜富含多不饱和脂肪酸并直接与血液中的氧分子接触,容易受到体内自由基的脂质过氧化攻击而受损。随着海拔的升高,低压缺氧、紫外辐射等环境因素会促使体内红细胞代偿性增多,并引起红细胞膜特性的改变,而膳食抗氧化营养素的摄入有助于增强红细胞抗氧化系统的防御能力,减轻红细胞膜的氧化损伤。本文主要综述了海拔及抗氧化营养素与红细胞膜氧化损伤的关系。 Erythrocyte membrane is rich in polyunsaturated fatty acids and direct contact with the oxygen molecules in the blood, vulnerable to lipid peroxidation of free radical damage in the body. With the elevation, hypoxia, UV radiation and other environmental factors will promote the compensatory increase of red blood cells in the body, and cause changes in the characteristics of the erythrocyte membrane, while the intake of dietary antioxidants helps to enhance the antioxidant system of red blood cells Defense ability to reduce red cell membrane oxidative damage. This article reviews the relationship between altitude and antioxidant nutrients and erythrocyte membrane oxidative damage.