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严重急性呼吸综合征(severe acute respiratory syndrome, SARS)冠状病毒、中东呼吸综合征冠状病毒(Middle Eastern respiratory syndrome coronavirus，MERS-CoV)及新型冠状病毒等冠状病毒感染肺炎的临床症状、病情进展及病理特征等有许多相似和相同之处，且与M1型巨噬细胞的功能相关。研究认为，肺组织M1巨噬细胞过度活化在CoV肺炎的发生、发展中起关键作用。以M1巨噬细胞为靶点的抗CoV肺炎治疗对于减轻症状、抑制病情进展及降低死亡率具有重要意义。“,”Coronavirus diseases, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome coronavirus (MERS-CoV) and Coronavirus disease 2019 (COVID-19), are a series of diseases with a lot of common features, characterized by fast progression and clinical symptoms such as persistent fever, cough, severe respiratory syndrome and kidney failure. Pathologically, the underlying mechanism is highly related to hyper activation and functionality of M1 macrophage. Therefore, selecting M1 macrophage as a therapeutic target for CoV Diseases could be a potent method to alleviate symptoms, suppress disease progression, and eventually, reduce mortality.