冠心病(CHD)居北欧,北美等西方国家疾病死因之首。尽管我国人群CHD发病率较之为低,但心血管疾病(CVD)现也已上升为威胁我国人民健康的第一大疾病。CHD发病的诸因素中,脂质异常、高血压、吸烟为三大主要危险因素。本文试图从流行病学、病理形态改变及高脂蛋白血症HLP方面概述脂质因素在动脉粥样硬化(Atherosclerosis,As)中的作用。一、脂蛋白、载脂蛋白的分类、结构与功能(?)根据血浆脂蛋白(Lipoprotein Lp)密度不同,用超离心法可将其分为CM、VLDL、IDL、LDL、HDL和Lp(a)等。它们都含甘油三酯(TG)和胆固醇酯(CE)组成的疏水核心。外围是由单层磷脂(PL)包绕。亲水表面还含少量未酯化胆固醇(UC)和载脂蛋白(Apolipoprotein Apo)。根据所含成分的比例不同,又可分为富含TG的Lp(CM和VLDL)和富含胆固 Coronary heart disease (CHD) in North Europe, North America and other western countries the first cause of death. Although the incidence of CHD is lower in our population, cardiovascular disease (CVD) has now risen to be the number one disease that threatens the health of our people. CHD incidence of various factors, lipid abnormalities, hypertension, smoking are the three major risk factors. This article attempts to outline the role of lipid factors in atherosclerosis (As) in terms of epidemiology, pathological changes and HLP in hyperlipoproteinemia. Classification, Structure and Function of Lipoprotein and Apolipoprotein (?) According to the density of plasma lipoprotein (Lp), they can be divided into CM, VLDL, IDL, LDL, HDL and Lp )Wait. They all contain a hydrophobic core of triglycerides (TG) and cholesterol esters (CE). The periphery is surrounded by a single layer of phospholipid (PL). Hydrophilic surface also contains a small amount of unesterified cholesterol (UC) and apolipoprotein Apo. According to the different proportions of the contained components, it can be further divided into TG-rich Lp (CM and VLDL)