目的探讨立体定向放疗(SBRT)治疗肺部肿瘤的近期疗效及安全性。方法选取肺部肿瘤患者24例,其中原发性肺癌16例,肺转移癌8例;病灶直径1.5~3.5cm。采用SBRT治疗,肿瘤病灶照射剂量50~64Gy/5~12F/2~3周,每周一、三、五放疗(分次量为5Gy时为每日1次),周末不放疗。放疗结束后1个月和3个月复查胸部CT,观察近期疗效及放疗相关反应。结果 24例患者均顺利完成放疗,有效率95.8%。1级放射性肺炎14例,2级放射性肺炎2例,Ⅰ、Ⅱ度骨髓抑制各1例,无胸痛发生,生活质量明显改善。结论 SBRT治疗原发或继发性肺部肿瘤安全、有效,不良反应少。 Objective To investigate the short-term efficacy and safety of stereotactic radiotherapy (SBRT) in the treatment of lung cancer. Methods Twenty-four patients with lung cancer were selected, of which 16 were primary lung cancer and 8 were lung metastases. The diameter of lesions was 1.5-3.5 cm. Using SBRT treatment, tumor lesions irradiation dose of 50 ~ 64Gy / 5 ~ 12F / 2 ~ 3 weeks, every Monday, Wednesday and Friday radiotherapy (fraction 5Gy times a day), the weekend without radiotherapy. Chest CT was reviewed at 1 month and 3 months after the end of radiotherapy, and the short-term efficacy and radiotherapy-related response were observed. Results All the 24 patients received radiotherapy successfully, with an effective rate of 95.8%. 14 cases of grade 1 pneumonia, 2 cases of grade 2 pneumonitis, and 1 case of grade Ⅰ and Ⅱ myelosuppression. There was no chest pain and quality of life improved significantly. Conclusion SBRT is safe and effective in treating primary or secondary lung cancer with fewer adverse reactions.