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维生素A酸(RA)能够诱导人的急性早幼粒白血病细胞系HL-60向成熟粒细胞方向分化.临床上RA已作为治疗急性早幼粒白血病及前白血病的药物.分化后,细胞的生长状况、细胞功能及表面抗原的表达均发生变化.我们采用NBT还原反应及吞噬发光实验观察诱导前后细胞功能的变化.并采用间接免疫荧光的方法,使用流式细
Vitamin A acid (RA) can induce human acute promyelocytic leukemia cell line HL-60 to differentiate into mature granulocytes.Clinical RA has been used as a medicine for the treatment of acute promyelocytic leukemia and leukemia.After differentiation, the growth of cells The cell function and the expression of cell surface antigen changed.We used NBT reduction reaction and phagocytosis to observe the changes of cell function before and after induction.And using indirect immunofluorescence method,