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某些研究认为动物的色素表型与内耳对氨基糖甙类耳毒性的敏感性有关。耳蜗内的血管纹富含黑色素,可以和某些药物结合。Lindquist认为色素的存在很可能成为引起药物耳毒性病损的一个原因。作者用有色豚鼠进行给予不同剂量庆大霉素耳蜗毒性的实验研究。将36只动物等分为三组,每组注射和对照各6只。三个注射组分别给予50、75和100mg/kg庆大霉素,连续皮下注射10天;对照组只注射等量盐水。试验期间观察
Some studies suggest that the pigmentation phenotype in animals is related to the sensitivity of the inner ear to ototoxicity of aminoglycosides. Vasculature in the cochlea is rich in melanin and can bind to certain drugs. Lindquist believes that the presence of pigment is likely to be one of the causes of drug ototoxicity. The authors used colored guinea pigs to give different doses of gentamycin cochlear toxicity. Thirty-six animals were equally divided into three groups of 6 injections and 6 in each group. Three injection groups were given gentamycin 50,75 and 100mg / kg, continuous subcutaneous injection of 10 days; the control group was injected with an equal amount of saline. Observation during the experiment