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为了探讨热疗联合化疗治疗晚期胃癌腹水的临床疗效,对9例伴有腹水的晚期胃癌患者,利用内生场局部热疗仪治疗腹部转移病灶,加温至41℃,持续1h,配合顺铂40mg/m2腹腔给药,多西他赛30mg/m2静脉滴入化疗,均每周1次,连续3周为1个周期。观察腹水疗效、腹部实体病灶缓解程度和热化疗后的不良反应。结果热化疗后9例患者中有3例腹水消退,6例腹水得到控制;腹部可测量病灶部分缓解4例,稳定2例;没有出现热化疗不良反应叠加。初步研究结果提示,热疗联合顺铂腹腔给药与多西他赛静脉滴入能够较好控制晚期胃癌腹水,并可获得较好的局部病灶缓解。
In order to explore the clinical efficacy of hyperthermia combined with chemotherapy in the treatment of advanced gastric cancer ascites, nine patients with advanced gastric cancer with ascites were treated with endometrial local hyperthermia instrument for the treatment of abdominal metastasis. The lesions were heated to 41 ℃ for 1 hour, Intraperitoneal administration of 40mg / m2, docetaxel 30mg / m2 intravenous chemotherapy, were 1 week, for 3 weeks for a cycle. To observe the curative effect of ascites, the degree of remission of solid lesions in the abdomen and the adverse reaction after thermal chemotherapy. Results In 9 patients after chemotherapy, 3 cases of ascites subsided, 6 cases of ascites were controlled; 4 cases of partial remission measurable in the abdomen, stable in 2 cases; no adverse effects of thermal chemotherapy superimposed. Preliminary results suggest that hyperthermia combined with cisplatin intraperitoneal administration and docetaxel intravenous infusion can better control advanced gastric ascites and obtain better local remission.