论文部分内容阅读
问:我有一亲戚因急性心肌梗塞住院,持续用消心痛治疗1天后,第二天胸闷痛症状又复出且较前加剧,医生说这是耐药现象。请问这是为什么?如何预防和处理?宁夏银川方林答:消心痛属于硝酸酯类药物。临床研究表明,如果持续用药可能会产生耐药现象而使病情反复,甚至出现其他不良作用。这是因为硝酸酯类进入平滑肌细胞内,在巯基的参与下,经过某些生化过程分解成氧化氮,再形成亚硝酸硫醇。后者通过一系列反应使硝酸酯类无法发挥作用,因而出现耐药现象。此外,持续使用硝酸
Q: I have a relative hospitalized for acute myocardial infarction, continued treatment with defoaming pain after 1 day, the next day the symptoms of chest pain and back again increased, the doctor said that this is the phenomenon of resistance. Is this why? How to prevent and deal with? Ningxia Yinchuan Fanglin A: eliminate heartache belong to nitrates. Clinical studies have shown that if continued drug use may result in drug resistance and make the disease repeated, and even other adverse effects. This is because nitrate into the smooth muscle cells, with the participation of thiol, after some biochemical processes decompose into nitric oxide, and then form a nitrite thiol. The latter through a series of reactions nitrates can not play a role, resulting in resistance phenomenon. In addition, nitric acid is used continuously