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目的:对比研究血清一氧化氮(NO)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)在急性胆源性胰腺炎(ABP)和正常对照组之间的差别,以探讨各指标的意义。方法:随机选择临床ABP患者40例,分为轻症ABP(MABP)与重症ABP(SABP)二型,门诊健康体检者50例作为对照,分别检测血清NO、SOD、CAT的浓度。结果:ABP患者血清NO和CAT浓度比对照组明显升高(P<0.01),且SABP比MABP升高更明显(P<0.01)。SOD比对照组明显降低(P<0.01),且SABP下降更明显(P<0.05)。结论:NO和CAT参与了ABP的发病,且与ABP的病情呈正相关。SOD在ABP组随病情加重而下降,提供外源性SOD可能可以减轻ABP的病情。
Objective: To compare the differences of serum nitric oxide (NO), superoxide dismutase (SOD) and catalase (CAT) between acute biliary pancreatitis (ABP) and normal control group The significance of the indicator. Methods: A total of 40 patients with clinical ABP were randomly selected and divided into mild ABP (MABP) and severe ABP (SABP) type II and 50 outpatients with physical examination as control. Serum levels of NO, SOD and CAT were measured respectively. Results: Serum concentrations of NO and CAT in patients with ABP were significantly higher than those in control group (P <0.01), and SABP levels were significantly higher than those in MABP group (P <0.01). SOD was significantly lower than that of the control group (P <0.01), and SABP decreased more significantly (P <0.05). Conclusion: NO and CAT are involved in the pathogenesis of ABP and are positively correlated with the severity of ABP. SOD in the ABP group decreased with the severity of the disease, providing exogenous SOD may be able to reduce the ABP’s condition.